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Cord-Blood Transplantation in Patients with Minimal Residual Disease

Filippo Milano MD. Ph.D, Ted Gooley Ph.D, Brent Wood M.D, Ann Woolfrey M.D., Mary Flowers M.D, Kristine Doney M.D, Robert Witherspoon M.D, Marco Mielcarek M.D, Joachim Deeg M.D, Mohamed Sorror M.D, Ann Dahlbery M.D, Brenda Sandmaier M.D, Rachel Salit M.D, Effie Petersdorf M.D, Frederick Applebaum M.D, Colleen Delaney M.D Clinical Research Division, Fred Hutchinson Cancer Research Center and the Departments of Medicine and Pediatrics, University of Washington

“Bone marrow transplants can treat and even cure some types of genetic disorders and blood diseases. Key to this potentially life-saving procedure is finding a matching donor. Not all patients, however, are able to find a match among their relatives. In those cases, searching for an unrelated, matched donor can be a long, stressful, and possibly unsuccessful process—especially for ethnic and racial minorities.

Blood from human umbilical cords acquired soon after a baby is born contains a small number of the adult stem cells that mature into healthy blood cells. Umbilical cord blood donation poses little risk to donors, and the life-saving blood can be stored frozen for years” (National Heart, Lung, and Blood Institute, 2012).

A study conducted on patients with acute leukemia or myelodysplastic syndrome, conducted by the staff at the Clinical Research Division, Fred Hutchinson Cancer Research Center and the Departments of Medicine and Pediatrics, University of Washington, found that the relative risks of death and relapse between the cord-blood group and the two-other unrelated-donor groups appeared to vary per the presence of minimal residual disease status before transplantation. The risk of death was higher in the HLA-mismatched group than in the cord-blood group. Most patients in need of a hematopoietic-cell transplant do not have a match related donor. It also shows relapse rates were lowest in Cord Blood Transplants compared to un-related donors (matched and mismatched).

Cord Blood Study

Please click the link below to learn more about the study.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513721/

 

National Cord Blood Awareness Month. (2012, July 09). Retrieved July 26, 2017, from https://www.nhlbi.nih.gov/about/directorscorner/messages/national-cord-blood-awareness-month

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